George Klotter left the Klotter, Sohn, & Co. Brewery partnership to pursue his own proprietorship, at which point Johann George Sohn brought in Louis Sohngen and Heinrich Schlosser as partners. The new partnership would operate under the name of J.G. Sohn & Co. Brewery. Sohn ran the business until his death in 1876.
After Sohn's death, leadership of the company was assumed by his sons, J.G. Sohn Jr., William, and J. Edward. J.G. Sohn Jr. died in 1880 and the other two brothers continued to operate the brewery together until 1900, at which time J. Edward left to join the Schaller Brothers Brewery. Shortly thereafter William would rename the brewery as the William S. Sohn Brewery, however he died in 1902. After William's death his wife, Lena Jung Sohn ran the brewery until 1907, as she was intimately familiar with the industry by way of her father, another Cincinnati brewer.